Landmark ALL-RISE Trial results
and simultaneously published in the
CathWorks FFRangio Demonstrated Similar Clinical Outcomes to Pressure Wire-guided Treatment
CathWorks FFRangio is the only FDA-approved angiography-derived physiology (ADP) technology proven to FFR/NHPR in MACE* outcomes
All-cause Death
Myocardial Infarction
Revascularization
*
MACE = All-cause death, myocardial infarction (MI) or unplanned clinically-driven revascularization
Similar Safety Profile
CathWorks FFRangio had a similar safety profile as pressure
Bleeding
Major Bleeding at 30 Days
Improved Resource Utilization
CathWorks FFRangio reduced radiation exposure and the use of contrast medium compared to pressure wire-guided treatment.
Flouroscopy Time
Use of Contrast Medium
Reduced Procedure Time
CathWorks FFRangio reduced analysis time and overall procedure time compared to pressure wire-guided treatment.
Analysis Time
Overall Procedure Time
CathWorks FFRangio:
The New Standard of Care in Coronary Physiology
Study Objective
The objective of the ALL-RISE Trial was to assess whether CathWorks FFRangio is comparable to conventional pressure wire-based (FFR/NHPR) assessment of intermediate lesions being considered
Study Design
Patients presenting with coronary stenoses of intermediate significance were randomized to physiological assessment with CathWorks FFRangio (FFRangio group; 965 patients) or an invasive pressure wire-based approach (pressure wire group; 965 patients). Participating sites could choose whether the patients randomized to the pressure wire group were assessed with fractional flow reserve (FFR), requiring drug stimulation, or non-hyperemic pressure
Participating Sites
The ALL-RISE Study included 59 sites across North America, Asia, Europe and the
California
Kaiser Permanente San Francisco
San Francisco, CA
Principal Investigator:
Gopi K. Manthripragada, MD
Ronald Reagan UCLA Medical Center
Los Angeles, CA
Principal Investigator:
Rushi V. Parikh, MD
St. Joseph Medical Center
Stockton, CA
Principal Investigator:
Cyrus Buhari, MD
Stanford University
Stanford, CA
Principal Investigator:
William Fearon, MD
UC San Diego - Sulpizio Cardiovascular Center
La Jolla, CA
Principal Investigator:
Ehtisham Mahmud, MD
University of Southern California - Keck Medical Center
Los Angeles, CA
Principal Investigator:
Ray Matthews, MD
VA Long Beach Healthcare System - Tibor Rubin VA Medical Center
Long Beach, CA
Principal Investigator:
Arnold Seto, MD
VA Palo Alto Healthcare System
Palo Alto, CA
Principal Investigator:
William Fearon, MD
Florida
HCA Florida JFK Hospital
Atlantis, FL
Principal Investigator:
Mark Rothenberg, MD
HCA Florida Northside Hospital - Bay Area Heart
St. Petersburg, FL
Principal Investigator:
Ali Jabbar, MD
The Cardiac and Vascular Institute Research Foundation
Gainesville, FL
Principal Investigator:
Christopher Estel, MD
Tallahassee Research Institute, Inc.
Tallahassee, FL
Principal Investigator:
William C. Dixon, IV, MD
University of Miami
Miami, FL
Principal Investigator:
Ioannis S. Chatzizisis, MD
University of South Florida / Tampa General Hospital
Tampa, FL
Principal Investigator:
Hiram Bezerra, MD
Georgia
Cardiovascular Consultants of South Georgia, LLC - Archbold Medical Center
Thomasville, GA
Principal Investigator:
Clay Sizemore, MD
Illinois
Carle Foundation Hospital
Urbana, IL
Principal Investigator:
Issam Moussa, MD
Kansas
Ascension Via Christi Hospitals Wichita, Inc.
Wichita, KS
Principal Investigator:
Bassem Chehab, MD
Kentucky
St. Elizabeth Healthcare - Heart & Vascular Institute
Edgewood, KY
Principal Investigator:
Mohan Brar, MD
Maryland
MedStar Union Memorial Hospital
Baltimore, MD
Principal Investigator:
John Wang, MD
TidalHealth Peninsula Regional Hospital
Salisbury, MD
Principal Investigator:
Steven Hearne, MD
Massachusetts
Beth Israel Deaconess MC
Boston, MA
Principal Investigator:
Robert Yeh, MD
Michigan
Henry Ford Health St. John
Detroit, MI
Principal Investigator:
Amir Kaki, MD
Minnesota
Metropolitan Heart and Vascular Institute
Coon Rapids, MN
Principal Investigator:
Matthew Whitbeck, MD
Minneapolis Heart Institute Foundation
Minneapolis, MN
Principal Investigator:
Yader Sandoval, MD
Mississippi
Cardiology Associates of North Mississippi, PA
Tupelo, MS
Principal Investigator:
Jonathan Blossom, MD
New Jersey
Mountainside Medical Center
Montclair, NJ
Principal Investigator:
Ankitkumar Patel, MD
The Valley Hospital
Paramus, NJ
Principal Investigator:
Rajiv Tayal, MD
New York
Catholic Health St. Francis Hospital & Heart Center
Roslyn, NY
Principal Investigator:
Evan Shlofmitz, DO
Columbia University / NewYork-Presbyterian Hospital
New York, NY
Principal Investigator:
Margaret B. McEntegart, MD
Ellis Hospital
Schenectady, NY
Principal Investigator:
Aakash Garg, MD
NewYork-Presbyterian Brooklyn Methodist Hospital
Brooklyn, NY
Principal Investigator:
Yuhei Kobayashi, MD
Northwell Health
New York, NY
Principal Investigator:
Michael Kim, MD
NY Presbyterian Hospital - Weill Cornell Medicine
New York, NY
Principal Investigator:
Geoffrey W. Bergman, MD
NYU Langone Health - NYU Grossman SOM
New York, NY
Principal Investigator:
Louai Razzouk, MD
Ohio
Mount Carmel Health - Grove City
Grove City, OH
Principal Investigator:
Michael Buschur, MD
The Christ Hospital Health - The Lindner Research Center
Cincinnati, OH
Principal Investigator:
Santiago A. Garcia, MD
Pennsylvania
Hospital of the University of Pennsylvania
Philadelphia, PA
Principal Investigator:
Daniel Kolansky, MD
Lehigh Valley Health Network
Allentown, PA
Principal Investigator:
Shailendra Singh, MD
Texas
Baylor Scott & White - The Heart Hospital
Plano, TX
Principal Investigator:
Karim Al-Azizi, MD
HCA Methodist San Antonio - Cardiology Clinic of San Antonio
San Antonio, TX
Principal Investigator:
Nandish Thukral, MD
Virginia
Inova Fairfax Hospital
Falls Church, VA
Principal Investigator:
Behnam Tehrani, MD
Aichi Prefecture
Ichinomiyanishi Hospital
Ichinomiya, Aichi
Principal Investigator:
Kazuhiro Dan, MD
Chiba Prefecture
Chibanishi General Hospital
Matsudo, Chiba
Principal Investigator:
Kazuo Misumi, MD
Gifu Prefecture
Gifu Heart Center
Gifu, Gifu
Principal Investigator:
Hitoshi Matsuo, MD
Hiroshima Prefecture
Fukuyama Cardiovascular Hospital
Fukuyama, Hiroshima
Principal Investigator:
Kikuta Yuetsu, MD
Hyogo Prefecture
Kobe University Hospital
Kobe, Hyogo
Principal Investigator:
Hiromasa Otake, MD
Mie Prefecture
Mie University Hospital
Tsu, Mie
Principal Investigator:
Tairo Kurita, MD
Tokyo
NTT Medical Center Tokyo
Tokyo, Tokyo
Principal Investigator:
Takayuki Warisawa, MD
Sakakibara Heart Institute
Fuchu, Tokyo
Principal Investigator:
Mamoru Nanasato, MD
Switzerland
Centre Hospitalier Universitaire Vaudois (CHUV)
Lausanne, Switzerland
Principal Investigator:
Stéphane Fournier, MD
Hôpital Cantonal de Fribourg (HFR)
Villars-sur-Glâne, Switzerland
Principal Investigator:
Stéphane Cook, MD
Hôpitaux universitaires de Genève (HUG)
Geneva, Switzerland
Principal Investigator:
Juan F. Iglesias, MD
United Kingdom
Imperial NHS Foundation Trust - Hammersmith Hospital
London, United Kingdom
Principal Investigator:
Rasha Al-Lamee, MD
Mid and South Essex NHS Foundation Trust - Basildon University Hospital
Basildon, United Kingdom
Principal Investigator:
Thomas Keeble, MD
Somerset NHS Foundation Trust - Musgrove Park Hospital
Taunton, United Kingdom
Principal Investigator:
Mohammad Sahebjalal, MD
Rabin Medical Center
Petah Tikva, Israel
Primary Investigator:
Amos Levi, MD
Rabin Medical Center - Golda Hasharon Hospital
Petah Tikva, Israel
Primary Investigator:
Gabriel Greenberg, MD
1.
Kirtane AJ et al. A large-scale, global randomized trial of coronary physiology derived from conventional angiography compared with an invasive pressure wire-based approach to guide percutaneous coronary intervention, as presented at ACC 2026. ClinicalTrials.gov number NCT05893498.
2.
Fearon WF et al. Angiography-derived fractional flow reserve to guide PCI. N Engl J Med, published on March 29, 2026. DOI: 10.1056/NEJMoa2600949.